Cotton (Gossypium spp.), often hailed as “white gold”, is a vital fiber crop providing raw material for the global textile industry. The growth and productivity of this exceptional crop can, however, be adversely impacted by salt damage. Cui et al. employed transcriptome analysis and identified GhPP2C43, a gene from semi-wild yucatanense cotton, as a significant enhancer of salt tolerance in cotton plants. These findings not only provide further insight into the mechanisms underlying salt tolerance but also an opportunity for developing new cotton germplasms resistant to salt stress.