Vitis zhejiang-adstricta (V. zhejiang-adstricta) is an endangered wild grape endemic to China, which has significant disease resistance. In this issue, Li et al . present the high-quality assembled diploid genome of V. zhejiang-adstricta (IB-VB-01) comprising 506.66 Mb, with 19 pseudochromosomes and 31,196 annotated protein-coding genes. Comparative genome and evolutionary analysis revealed that V. zhejiang-adstricta holds a specific position in the evolution of East Asian Vitis, which diverged with Vitis vinifera from a common ancestor between 9.34-11.12 Mya. Analysis of gene expansion and contraction families further identified the evolution of unique and common gene families related to environmental adaptability. The near-complete and accurate reference genome of V. zhejiang-adstricta provides a valuable genomic resource for ameliorating disease resistance breeding strategies in grape.