We will bring together researchers who are exploring the frontiers of tree evolution, ecology, and development using next generation sequencing, genomics, and systems biology approaches. Together, we hope to inspire new ideas for collaborative research that will bring together currently disjoint research communities, and usher in a new era of genome-based forest biology. Ultimately, the approaches and insights from genome-based forest biology will inform us how to address problems ranging from forest conservation during climate change to tailoring of tree-based biofuels feedstocks.